Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3014
Gene Symbol: H2AX
H2AX
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 PosttranslationalModification BEFREE γ-H2AX phosphorylation after bleomycin treatment in PBL did not differ between CRC and BC patients. 29052312

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 Biomarker BEFREE β-Galactoside α-2,6-sialyltransferase 1 (ST6Gal1) catalyzes EGFR sialylation that is associated with gefitinib resistance in colorectal cancers, and this was also investigated. 30187356

2018

Entrez Id: 6480
Gene Symbol: ST6GAL1
ST6GAL1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.080 Biomarker BEFREE β-Galactoside α-2,6-sialyltransferase 1 (ST6Gal1) catalyzes EGFR sialylation that is associated with gefitinib resistance in colorectal cancers, and this was also investigated. 30187356

2018

Entrez Id: 3661
Gene Symbol: IRF3
IRF3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.020 Biomarker BEFREE β-catenin regulates IRF3-mediated innate immune signalling in colorectal cancer. 30004146

2018

Entrez Id: 9368
Gene Symbol: SLC9A3R1
SLC9A3R1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.080 Biomarker BEFREE β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy. 29551770

2018

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE β-Arrestins (Arrb) participate in the regulation of multiple signaling pathways, including Wnt/β-catenin, the major actor in human colorectal cancer initiation. 22315403

2012

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.080 Biomarker BEFREE α-enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer. 27996156

2017

Entrez Id: 5564
Gene Symbol: PRKAB1
PRKAB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.060 Biomarker BEFREE α-enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer. 27996156

2017

Entrez Id: 5563
Gene Symbol: PRKAA2
PRKAA2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.060 Biomarker BEFREE α-enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer. 27996156

2017

Entrez Id: 1398
Gene Symbol: CRK
CRK
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690

2019

Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690

2019

Entrez Id: 25897
Gene Symbol: RNF19A
RNF19A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690

2019

Entrez Id: 26073
Gene Symbol: POLDIP2
POLDIP2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690

2019

Entrez Id: 9402
Gene Symbol: GRAP2
GRAP2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690

2019

Entrez Id: 7965
Gene Symbol: AIMP2
AIMP2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690

2019

Entrez Id: 10598
Gene Symbol: AHSA1
AHSA1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690

2019

Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690

2019

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE [Corrigendum] Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK‑mediated DR5 regulation in colorectal cancer. 30864690

2019

Entrez Id: 283460
Gene Symbol: HNF1A-AS1
HNF1A-AS1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.030 Biomarker BEFREE [Corrigendum] Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma. 31257539

2019

Entrez Id: 125919
Gene Symbol: ZNF543
ZNF543
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker BEFREE ZNF397OS and ZNF543 represented the top scoring associated events that were further validated in an independent cohort and exhibited strong correlation with BMI and excellent and statistically significant efficiency in the discrimination of obese from non-obese CRC patients (area under the curve >0.80; p < 0.05). 29717273

2019

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.700 Biomarker BEFREE ZNF281 Regulates Cell Proliferation, Migration and Invasion in Colorectal Cancer through Wnt/β-Catenin Signaling. 31112017

2019

Entrez Id: 57541
Gene Symbol: ZNF398
ZNF398
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker BEFREE Zinc-finger protein p52-ZER6 accelerates colorectal cancer cell proliferation and tumour progression through promoting p53 ubiquitination. 31521611

2019

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/β-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer. 28677721

2017

Entrez Id: 7153
Gene Symbol: TOP2A
TOP2A
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.050 AlteredExpression BEFREE Zinc finger protein 148 (ZNF148) and TOP2A expression were analyzed in 742 colorectal cancer (CRC) tissues using immunohistochemistry (IHC). 28072746

2017

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.400 AlteredExpression BEFREE ZD9331, a highly specific TS inhibitor that dose not require polyglutamation for its activation, has shown activity in patients with refractory ovarian and colorectal cancer. 12450420

2002